Navegando por Assunto "Neoplasias do colo do útero"

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Cobertura do teste colpocitológico e fatores associados à não realização: um olhar sobre o programa de prevenção do câncer de colo do útero no estado do Pará
(Centro Universitário do Estado do Pará, 2022-11-14) Franco, Carolina Vinagre Pires; Amaral, Gabriela Borborema do; Rodrigues, Brenda Diniz; http://lattes.cnpq.br/6746290429073526; http://lattes.cnpq.br/9582500401192127; Caetano, Djenanne Simonsen Augusto de Carvalho; http://lattes.cnpq.br/0350756059004026; Dutra, Taísa Andrade Pereira; http://lattes.cnpq.br/4788667938871523
Cervical cancer represents an important public health problem. It is the fourth most frequent neoplasm among women in Brazil. Its prevention is performed in all women aged 25 to 64 years, through the cytopathological examination of the cervix, with a screening that enables the detection of lesions and thus early diagnosis of the disease. To analyze the data on the coverage of colpocytopathological testing in women in the state of Pará, Brazil, and the factors related to non-performance of the test. Descriptive epidemiological study conducted with data collection from SCAN and SISCOLO, made available by DATASUS. The total sample analyzed was 762,492 patients, among them, the search for screening of the disease was the main reason for performing the test (95.9%); the age range of greater realization was 30 to 34 years (13.33%). Both subtypes of adenocarcinoma were more prevalent between 40 and 44 years, being in situ (18.13%) and invasive (20.37%). The level of education was ignored in 98.38% of cases. The test was considered technically satisfactory in 97.41% and, among them, 39.40% had no endocervical or metaplastic cells. The colpocytological exam is the best method of screening and preventing of malignant neoplasms of the cervix, directly impacting the epidemiological rates of the disease, due to its early recognition and treatment. Measures such as awareness of women on the subject, proper training of health professionals who perform the collection, investment in health actions aimed at women, and proper completion of the notification forms on the platform are very important to improve the rates of cancer incidence and mortality, especially in the North region, which has the highest rates in Brazil.
Detecção do HPV nas lesões pré-câncer de colo uterino em laboratório na região Amazônica
(Centro Universitário do Estado do Pará, 2022-11-14) Alves, Emanuelle Ferreira; Magalhães, Marília Alvino de; Chagas, Elcimara da Paixão Ferreira; http://lattes.cnpq.br/4061268902131720; Rodrigues, Paloma Panzuti; http://lattes.cnpq.br/9380681051150645; Dutra, Taísa Andrade Pereira; http://lattes.cnpq.br/4788667938871523
Cervical cancer is the fourth most common among the Brazilian female population and, in global terms, it also ranks among the top positions. In 99% of cases, this cancer is caused by HPV infection, with genotypes 16 and 18 being the most involved. To identify the most common HPV genotypes in lesions classified as LIEBG and LIEAG. Samples of the uterine cervix were collected and submitted to cytopathological analysis, and those diagnosed with LIEBG or LIEAG had their DNA extracted and amplified. For HPV detection, the “Nested-PCR” technique was used with oligonucleotide primers MY9/MY11, and also GP5 and GP6; and for 6, 11, 16, 18, 31, 33, 35, 52 and 58 subtypes typing, real-time PCR was performed with specific probes. HPV was present in 45 (90%) of the 50 patients with LIEBG or LIEAG. In the 23 patients who had LIEBG and positive HPV DNA, the most common genotype was HPV 58 (34.78%). On the other hand, in the 22 patients with LIEAG and positive HPV DNA, the most common genotype was HPV 16 (50%). Disregarding the degree of intraepithelial lesion present, HPV 16 was the most common among the 45 women with positive HPV DNA. HPV infection was detected in most patients with squamous intraepithelial lesion, with types 16 and 58 being the most common. The virus genotypes found were similar between LIEBG and LIEAG, however HPV 16 had a prevalence twice as high in high-grade lesions in relation to low-grade lesions.
Detecção dos subtipos do papilomavírus humano em lesões precursoras do câncer do colo uterino em mulheres jovens
(Centro Universitário do Estado do Pará, 2020) Elias, Carina de Abreu; Baia, Rafael Miranda Pantoja; Chagas, Elcimara da Paixão Ferreira; http://lattes.cnpq.br/4061268902131720
Introduction: Cervical cancer is the third most prevalent type of cancer in Brazil and the first in the State of Pará. It is caused by HPV, which has more than 200 subtypes, and its precursor lesion is differentiated into low and high grade. Objective: to detect the most prevalent HPV subtypes in precursor lesions of cervical cancer in young women. Method: The samples come from a reference laboratory in Belém and consist of 27 biopsies of patients, who had positive PCR for HPV, divided into 3 groups, with 9 samples from patients with low-grade intraepithelial lesions, 3 samples from high-grade intraepithelial lesions and 7 samples with cervicitis used as a control group. The samples had the DNA isolated with a DNA extraction kit for paraffined block. Nested-PCR were performed to detect the presence of HPV DNA, and positive samples were subjected to real-time PCR for 7 probes of the following viral subtypes: 6, 11, 16, 18, 31, 33, 35, 52 and 58 Result: A total of 19 samples were HPV DNA positive. The prevalence of LIEBG was higher than that of LIEAG. The most prevalent HPV subtype was HPV 16, with a total of 3 samples in relation to the total subtypes. No HPV DNA 18, 31, 58 and 11 were found in any of the samples. Conclusion: The prevalence of HPV in young women was 70,3%. In women with cervicitis, the prevalence was 58,3%, in LIEBG it was 81,8% and in LIEAG 75%. The most prevalent HPV subtype was 16, with 15.7% of the total samples. Regarding cervicitis, the most prevalent subtypes were HPV 33 and HPV 52. In LIEBG there was no detection of any subtype tested in the samples. In LIEAG the most prevalent subtype was HPV 16, followed by HPV 35.
Perfil epidemiológico das pacientes com lesões precursoras e câncer do colo de útero atendidas em um Centro de Especialidades Médicas
(Centro Universitário do Estado do Pará, 2019) Silva, Giovanna Gomes e; Furtado, Lidia Lacerda; Campos, Ana Carla Araujo; http://lattes.cnpq.br/4066530269438763
Introduction: Carcinoma of the uterine cervix is the fourth most incident cancer in women in Brazil, in 2018, was expected 16.340 new cases of carcinoma of the uterine cervix in Brazil. At the region North, including Pará State, this cancer is the most incident at the female population, just behind non-melanoma skin cancer, where were diagnosed 820 new cases in 2016. The profile of women that develop this kind of cancer, stand out early age at first sexual intercourse, multiplicity of partners, history of sexually transmitted infections, use of the oral contraceptives, multiparity, early pregnancy and tabagism. Objectives: To describe epidemiological profile of patients with uterine cervix cancer treated at a specialized medical center. Methods: A descriptive and retrospective study was performed. Data were collected from medical records of patients diagnosed with uterine cervix cancer or precursor lesions from 2015 to 2018, sociodemographic information and main characteristics that are considered as risk factors for the development of the disease were collected. Results: The average age of the patients was 41,5 years, most were divorced, illiterate, multiparous, the first sexual intercourse occurred between 8 and 24 years and had altered cytopathological exams and colposcopy. Conclusion: The data analyzed allowed to characterize the epidemiological profile of patients with carcinoma of the uterine cervix and its precursor lesions in the population studied. These data have relevance in the implementation of public actions for patients with similar profiles, so that screening and early diagnosis can be performed.