Fotobiomodulação com led e parâmetros laboratoriais no contexto de mucosite oral após altas doses de metroextrato em pacientes infanto-juvenis

Abstract

Cancer is a major cause of death among children and adolescents; and chemotherapy is the most used modality. Among the oral complications developed during chemotherapy treatment, oral mucositis (OM) is the most observed and its treatment is extremely necessary. Photobiomodulation is capable of exerting an analgesic and healing effect on the patient, where it becomes a viable alternative for prevention and treatment in all stages of OM. Objective: to stipulate the effectiveness of LED in the prevention of OM during the treatment of children and adolescents. Method: retrospective analysis of 123 medical records of patients undergoing a photodynamic therapy protocol with LED for treatment and / or prevention of the main oral manifestations related to chemotherapy using the SALUX software (Porto Alegre, RS, Brazil). Results: The LED phototherapy protocol for the treatment and / or prevention of oral mucositis related to chemotherapy was applied in all 118 patients, where 28 patients (23.8%) evolved with OM, of which 10 (35.7% ) were classified as grade 1; 12 (42.9%) classified as grade 2 and 6 (21.4%) as grade 3, with no cases classified as grade 4. It was observed that patients without the prophylactic protocol with LED develop OM 35 times more than patients who received the protocol (p <0.0001). Patients who developed OM presented changes in blood indexes, mainly in hemoglobin, hematocrit, TGP and TGO. Conclusion: photodynamic therapy is effective in preventing OM in juvenile children undergoing chemotherapy, with laboratory values of hemoglobin, urea, TGO and TGP and clinical picture of febrile neutropenia as risk factors for the development of oral mucositis.