Análise comparativa de perfil epidemiológico e imuno-histoquímico em pacientes jovens com câncer de mama em clínica privada

Abstract

Breast câncer in Young people is considered an uncommon disease accounting for less than 7% for all women diagnosed with câncer in developed countries. In the last decade, there have been fundamental changes in the understanding of the biology of breast cancer, which has come to be understood as a group of diseases with different molecular characteristics identified by gene expression profiles. This was a longitudinal retrospective case-control study in which 60 patients with a diagnosis of breast cancer, 20 young patients (≤ 40 years), Case group (Gca) and 40 patients (contro lgroup - CG) were evaluated, These groups were subdivided into two age groups: Groups 1 (GC1) with patients aged 41-59 years and Control groups 2 (GC2) with patients aged 60 or over. The patients underwent oncologic surgery, in the period between May/2013 and October/2018. The mean age of the participants was 34.2 years; 85% had symptomatic diseases; the mean tumor size was 2.6cm; 20% had a first-degree family history, and 35% had loco regional lymph nodes in the study. Histopathological examination. Regarding Postoperative Staging, 1A was more frequent. The luminal profile A was found in 38.8% of the patients, followed by luminal B in 33.3% and triple in 27.8% in the case group. Differing from the literature, in which predominance of the B-luminal profile occurs. We conclude that the sample studied presented fewer aggressive cases than found in the literature in this age group. The diagnosis of breast câncer is a challenge in this age group because women do not usually do mammographic screening before 40 years. With the purpose of drawing attention and orientation regarding breast cancer in Young women and guiding health professionals, a primer was produced with the purpose of encouraging, whenever possible, the early diagnosis and better therapeutic conduct of the patients.