Efeitos comparativos da fotobiomodulação utilizando laser de baixa intensidade ou diodo emissor de luz na mucosite oral em pacientes pediátricos que receberam altas doses de metroextrato: estudo prospectivo, randomizado e controlado

Abstract

Purpose: The objective of this study was to compare the efficacy of photobiomodulation using low-level laser therapy (LLLT) or light emitting diode therapy (LEDT) devices for the prevention of oral mucositis in pediatric patients diagnosed with acute lymphoblastic leukemia undergoing chemotherapy with high doses of methotrexate (MTX). Methods: 80 patients were randomly divided into two groups: LLLT and LEDT. Both protocols were applied with the same energy and radiant exposure. The protocols started in the beginning of high doses MTX and finished when the patients were discharged from the hospital or there was oral mucositis resolution. The oral mucositis was assessed during each session in accordance to the World Health Organization (WHO) score. The patients self-assessed pain was scored on a visual analog scale (VAS). Results: the incidence of oral mucositis was similar to LLLT and LEDT, 10% and 12,5% respectively. Both groups required the same number of days to reach score of zero for mucositis and pain (p > 0.05) and there was no significant difference in mean VAS between the groups. Conclusions: These findings suggest that LEDT has similar effects to LLLT and can be a low cost and easy application tool to avoid and treat oral mucositis.