Tratamento da Hepatite C com os antivirais de ação direta: análise dos fatores interferentes na adesão ao tratamento e na resposta virológica sustentada em pacientes atendidos em um Centro de Especialidades Médicas em Belém-PA

Abstract

Viral hepatitis are public health problems in Brazil. They present modes of transmission that vary from fecal-oral, sexual, parenteral and vertical transmission. Hepatitis C is caused by the Hepacivirus of the Flaviviridae family, the subclinical development with unspecific symptoms contributes to the chronicity of inflammation, cirrhosis and untreated hepatocellular cancer, which are performed through Direct Action Antiviral Drugs that aim at Sustained Virological Response with an elimination plan of the disease. Evaluate the adhesion to treatment and its interfering factors in addition to the prevalence of co-infections and the therapeutic response of these patients to the use of Direct-Action Antiviral Drugs (DAA). The present undergraduate thesis analyzed patients with Hepatitis C treated in the city of Belém-PA in a Center of Medical Specialties. The descriptive and analytical cross-sectional study developed used the Pearson’s Chi-Square and the Fisher's Exact Test for statistical analysis of data collected from medical records. It was noted at the end of the data analysis of 167 patients that the highest prevalence of notifications was in the metropolitan region (91%) with a greater number of cases among females (53,3%), but with a higher prevalence of coinfections among men (64,3%), especially in the younger age group (21,4%) aged 22 to 39 years. It was identified that 48.5% of the patients being followed up were older than 60 years and in most cases had less than 2 years of the period between diagnosis and the beginning of treatment, a factor that did not influence the therapeutic response, which was promising in more than 80% of the medical records analyzed. It is important to emphasize that, based on the better governmental structuring of the testing models and with the simplification of the diagnosis of Hepatitis C over the years, it was possible to analyze patients who, by adhering to treatments with DAAs, managed to obtain a cure for Hepatitis C without major side effects and with higher quality of life.