Navegando por Assunto "Tumor maligno"

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    Ganglioneuroblastoma em adolescente: incidentaloma adrenal pós-COVID 19 - um relato de caso raro
    (Centro Universitário do Estado do Pará, 2021) Azevedo, Andressa Lima; Ferreira, Jéssika Araújo; Caldato, Milena Coelho Fernandes; http://lattes.cnpq.br/9477878606835309
    Introduction: Ganglioneuroblastoma (GNB) is a rare malignant tumor of the adrenal gland. Symptoms depend on the location of the mass effect or the existence of the metastasis. As for the diagnosis, tumors of the neural crest in adults are rare and there is a difficulty in differentiating them only by imaging exams. Objective: To report a case of rare adrenal pathology with an incidence of less than five cases per 1,000,000 children, discovered after Computed Tomography of the Chest performed as a protocol of the COVID-19 disease, making a comparison with the cases reported in the world literature. Method: This is a rare case report study associated with a review of articles published in the world literature on the topic of ganglioneuroblastoma in adults. Case report: We present the case of a previously healthy 18-year-old man was diagnosed with Covid-19 and performed a chest Computed Tomography (CT) scan that showed an incidentaloma described as an oval formation in the right retroperitoneum, anterior to the adrenal. An endocrinologist evaluated the patient with a complete normal physical examination, as well as a hormonal laboratory that proved to be normal. Specialist indicated diagnostic excision, a procedure performed laparoscopically. The pathological examination consisted of a right adrenal and a nodular mass. With diagnosis of GNB intermixed subtype. Conclusion: The patient in the reported case does not fit the disease presentation pattern. Few data are available on the diagnosis and treatment of adults with GNB, making clear the importance of case report publications on the subject.
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    O paradigma da eficácia da quimioterapia em associação com diferentes tratamentos adjuvantes no tratamento do retinoblastoma: uma revisão sistemática da literatura
    (Centro Universitário do Estado do Pará, 2025-05-27) Luz, Ana Flavia Cardoso; Alves, Carolina Ferreira; Costa, Tanise Nazaré Maia; Araújo, Rita Helena Vallinoto; http://lattes.cnpq.br/4089453459357945; http://lattes.cnpq.br/4471975369870057; Silva, Carolina Trindade Pinto da; http://lattes.cnpq.br/1462166625345308; Guerreiro, Maiana Darwich Mendes; http://lattes.cnpq.br/6008305625565373; Coutinho, Igor Jordan Barbosa; http://lattes.cnpq.br/1282626226442845
    The treatment of retinoblastoma, the most common malignant eye tumor in children, has considerably evolved with the combination of chemotherapy and adjuvant treatments. This study conducted a systematic literature review to analyze the effectiveness of chemotherapy associated with different adjuvant therapies, such as thermotherapy, cryotherapy, and immunotherapy, in controlling retinoblastoma. Through a comprehensive search strategy in electronic databases such as Scielo Brasil, PubMed, Google Scholar, Web of Science, and the Capes Journals Portal, 16 relevant studies published between 1988 and 2024 were identified and selected. The inclusion criteria, such as publication date, language (English or Portuguese), and relevance to the theme of this work, were rigorously applied to ensure the relevance of the selected articles. The selection of studies was carried out in two stages: initially, by reading the titles and abstracts, and then by fully evaluating the texts to verify their eligibility based on the established criteria. The qualitative and quantitative analysis of the extracted data revealed patterns and trends regarding the effectiveness of these therapeutic combinations. The methodological quality of the selected studies was evaluated using standardized tools, such as the Newcastle-Ottawa scale for observational studies. The results indicated that integrating chemotherapy with adjuvant treatments significantly improved clinical outcomes, promoting better vision preservation and reducing recurrence rates. However, variability in treatment response and the need for an individualized approach were highlighted as fundamental factors for therapeutic success. This systematic review reinforced the importance of a multimodal approach and continuous research to improve therapeutic strategies in the treatment of retinoblastoma, pointing to the need for future investigations that can consolidate and innovate clinical practices in this field.