Navegando por Assunto "Quimioterapia"

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    Fotobiomodulação com led e parâmetros laboratoriais no contexto de mucosite oral após altas doses de metroextrato em pacientes infanto-juvenis
    (Centro Universitário do Estado do Pará, 2021-04-16) Ferreira, Isabella Melo Brito; Guimarães, Douglas Magno; http://lattes.cnpq.br/6439076195866691; Tuji, Fabrício Mesquita; http://lattes.cnpq.br/8122254353290848; Lima, Rafael Rodrigues; http://lattes.cnpq.br/3512648574555468
    Cancer is a major cause of death among children and adolescents; and chemotherapy is the most used modality. Among the oral complications developed during chemotherapy treatment, oral mucositis (OM) is the most observed and its treatment is extremely necessary. Photobiomodulation is capable of exerting an analgesic and healing effect on the patient, where it becomes a viable alternative for prevention and treatment in all stages of OM. Objective: to stipulate the effectiveness of LED in the prevention of OM during the treatment of children and adolescents. Method: retrospective analysis of 123 medical records of patients undergoing a photodynamic therapy protocol with LED for treatment and / or prevention of the main oral manifestations related to chemotherapy using the SALUX software (Porto Alegre, RS, Brazil). Results: The LED phototherapy protocol for the treatment and / or prevention of oral mucositis related to chemotherapy was applied in all 118 patients, where 28 patients (23.8%) evolved with OM, of which 10 (35.7% ) were classified as grade 1; 12 (42.9%) classified as grade 2 and 6 (21.4%) as grade 3, with no cases classified as grade 4. It was observed that patients without the prophylactic protocol with LED develop OM 35 times more than patients who received the protocol (p <0.0001). Patients who developed OM presented changes in blood indexes, mainly in hemoglobin, hematocrit, TGP and TGO. Conclusion: photodynamic therapy is effective in preventing OM in juvenile children undergoing chemotherapy, with laboratory values of hemoglobin, urea, TGO and TGP and clinical picture of febrile neutropenia as risk factors for the development of oral mucositis.
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    O paradigma da eficácia da quimioterapia em associação com diferentes tratamentos adjuvantes no tratamento do retinoblastoma: uma revisão sistemática da literatura
    (Centro Universitário do Estado do Pará, 2025-05-27) Luz, Ana Flavia Cardoso; Alves, Carolina Ferreira; Costa, Tanise Nazaré Maia; Araújo, Rita Helena Vallinoto; http://lattes.cnpq.br/4089453459357945; http://lattes.cnpq.br/4471975369870057; Silva, Carolina Trindade Pinto da; http://lattes.cnpq.br/1462166625345308; Guerreiro, Maiana Darwich Mendes; http://lattes.cnpq.br/6008305625565373; Coutinho, Igor Jordan Barbosa; http://lattes.cnpq.br/1282626226442845
    The treatment of retinoblastoma, the most common malignant eye tumor in children, has considerably evolved with the combination of chemotherapy and adjuvant treatments. This study conducted a systematic literature review to analyze the effectiveness of chemotherapy associated with different adjuvant therapies, such as thermotherapy, cryotherapy, and immunotherapy, in controlling retinoblastoma. Through a comprehensive search strategy in electronic databases such as Scielo Brasil, PubMed, Google Scholar, Web of Science, and the Capes Journals Portal, 16 relevant studies published between 1988 and 2024 were identified and selected. The inclusion criteria, such as publication date, language (English or Portuguese), and relevance to the theme of this work, were rigorously applied to ensure the relevance of the selected articles. The selection of studies was carried out in two stages: initially, by reading the titles and abstracts, and then by fully evaluating the texts to verify their eligibility based on the established criteria. The qualitative and quantitative analysis of the extracted data revealed patterns and trends regarding the effectiveness of these therapeutic combinations. The methodological quality of the selected studies was evaluated using standardized tools, such as the Newcastle-Ottawa scale for observational studies. The results indicated that integrating chemotherapy with adjuvant treatments significantly improved clinical outcomes, promoting better vision preservation and reducing recurrence rates. However, variability in treatment response and the need for an individualized approach were highlighted as fundamental factors for therapeutic success. This systematic review reinforced the importance of a multimodal approach and continuous research to improve therapeutic strategies in the treatment of retinoblastoma, pointing to the need for future investigations that can consolidate and innovate clinical practices in this field.