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    Análise da IL-10 em pacientes portadores do HIV-1 com periodontite crônica no norte do Brasil
    (Centro Universitário do Estado do Pará, 2018-03-09) Fonseca, Ricardo Roberto Souza; Menezes, Silvio Augusto Fernandes de; http://lattes.cnpq.br/5394614146901551; Celestino Júnior, Aluísio Ferreira; http://lattes.cnpq.br/6186863425175415; Rodrigues, Tânia Maria de Souza; http://lattes.cnpq.br/4924941383324071
    Aim: The objective of this study was to investigate the levels of IL-10 in the gingival crevicular fluid in HIV-1 positive patients with chronic periodontitis and to compare with HIV-1 negative patients with chronic periodontitis, also to correlate clinical periodontal parameters, viral load and count of CD4+ and CD8+ lymphocytes (LTCD4+ and LTCD8+). Methods: 33 patients were selected and splitted into two groups: 16 HIV-1 positive patients and 17 HIV-1 negative patients and all with chronic periodontitis. The clinical periodontal parameters recorded were: Probing Depth (PD) and Clinical Attachment Level (CAL); the sistemical parameters LTCD4+, LTCD8+ and viral load were analized by the gingival crevicular fluid collected from all patients. Enzymelinked immunosorbent assay (ELISA) was used to determine the concentrations of Interleukin (IL)-10. For the statistical analysis the Student t, Mann-Whitney and Spearman tests were performed. IL-10 levels were significantly lower in both patients groups. Results: There was statistical difference betwen groups for probing depth (p=0.015) and clinical attachment level (p=0.011), no significant correlation was found among the analyzed variables. Conclusion: The IL-10 levels in HIV-1 positive patients had no influence in periodontal and immonological parameters.