Navegando por Assunto "Giro denteado"

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Avaliação da população astrocitária de CA1, CA3 e giro denteado do hipocampo associada à alteração da atividade mastigatória em modelo murino
(Centro Universitário do Estado do Pará, 2020) Marta, Maria Helena Moutinho; Normando, Marina Paula Nobre; Mendes, Fabíola de Carvalho Chaves de Siqueira; Sosthenes, Marcia Consentino Kronka; http://lattes.cnpq.br/7881527576747420; http://lattes.cnpq.br/1890695030888456
The masticatory activity has been the subject of scientific studies not only for its participation as a facilitator of the process of ingestion/absorption of food, but also by the possible influence on brain function. The removal of the molar teeth of mice, for example, was capable of causing damage to the spatial location of middle-aged animals submitted to behavioral tests, and aggravated in advanced age, reinforcing the idea that the restriction of this activity accentuates cognitive decline. Faced with such a relevant theme, this work has The objective of this study was to investigate whether the alteration of masticatory activity, induced in a model young murine, influences the laminar distribution of astrocytes in the hippocampus. Like this 15 mice were, over 6 months, distributed into different groups of according to the presentation of the ration. One group received feed in the form of pellets. Another group, interspersed, received pelleted feed followed by feed meal, and the last group, also interspersed, received the pelleted feed, followed by bran and again pelleted. Brain material was extracted, and submitted to immunohistochemical processing and subsequent numerical estimation by Use of the optical fractionator of the laminarly organized astrocyte population in CA1, CA3 and Dentate Gyrus of the hippocampus. As a result, a reduction of the astrocyte population in those animals that had less incentive to masticatory activity in the CA1 region, while there was no difference in the of CA3 and toothed gyre. It was concluded that this result can be explained by the heterogeneity of each hippocampal region, as well as by the connections of the circuit trisynaptic and alternative memory formation.
Influência da atividade mastigatória sobre a morfometria de astrócitos do giro denteado em modelo murino
(Centro Universitário do Estado do Pará, 2020) Couto, Lucas Martins do; Braga, Rafael Ramos; Mendes, Fabíola de Carvalho Chaves de Siqueira; Sosthenes, Marcia Consentino Kronka; http://lattes.cnpq.br/7881527576747420; http://lattes.cnpq.br/1890695030888456
The decrease in masticatory activity is a process that has been proven to influence several aspects of cognition, especially those related to hippocampal functions. Based on this, the present study evaluated the influence of masticatory activity on the morphology of astrocytes in the outer third of the molecular layer of the dentate gyrus by means of three-dimensional reconstruction. With this objective, 15 animals were grouped in different ways according to the isolated or combined supply of diets in different consistencies, called pellet (solid feed) and bran feed. Thus, the HD control group (Hard diet), the group with reduced HD/SD masticatory activity (Hard diet/Soft diet) and the group with HD/SD/HD (Hard Diet/Soft diet/Hard diet) masticatory rehabilitation were formed. At six months of age, brain sections were obtained submitted to immunohistochemical processing for labeling glial fibrillary acidic protein (GFAP), present mainly in astrocytes. The variable chosen for comparison between the experimental groups was astrocyte complexity, as this was a common multimodal variable in all experimental groups. As a result, we detected, in all groups, the composition of two subfamilies of astrocytes: one of greater complexity and the other of less complexity, so-called Type I and Type II, respectively. When comparing each subtype between the diets, the HD group showed greater complexity compared to the groups of masticatory activity alteration (one-way ANOVA, post hoc T test, p< 0.05), both for type I and II. while its reduction negatively impacts the complexity and number of branches, which could affect the function of these cells.