Navegando por Assunto "Carcinoma basocelular"

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Análise transversal da casuística de câncer não-melanoma atendida no serviço de dermatologia do Centro de Especialidades Médicas do Centro Universitário do Estado do Pará (2012-2020)
(Centro Universitário do Estado do Pará, 2022-11-10) Dória, Beatriz Cavalcanti; Monteiro, Bruna Nogueira; Texeira, Cláudio Eduardo Corrêa; http://lattes.cnpq.br/7448998858430931; Amin, Gabriela Athayde; http://lattes.cnpq.br/8604283847300465; Moutinho, Ana Thais Machado; http://lattes.cnpq.br/3065574302582680
The skin is the largest organ in the human body. Among the diseases that can affect it, that is the skin cancer, which is of great relevance to the public health. To carry out a sectional analysis of the non-melanoma cancer series treted at the Dermatology Service of the Medical Specialties Center (CEMEC) of the University Ceter of the State of Pará (CESUPA, 2012-2020). Observational, cross-sectional, analytical and descriptive study. Data were collected directly from the medical records of patients treated at the Center for Medical Specialties of CESUPA between 2012 and 2020. After pre-analysis, the sample consisted of n = 65 of all patients seen, who have a diagnosis of skin cancer non-melanoma evidenced by biopsy. Data analysis was performed by comparing prevalent proportions with the “N-1” chi-square test (n = 65, ⍺ = 0,05, Cohen’s D: 0,2, test power: < 0,25) and by calculating the 95% confidence interval for the difference in prevailing proportions. The entire analytical process was performed using the R statistical computing program (www.r-project.org). In the period evaluated, it was evident that, within this sample, the prevalence of elderly people ( n = 50) was higher that that of adults (n = 15). Regarding gender, there was a predominance of females (n = 39). Addressing the phototype, IV (n = 18) prevailed in relation to III (n = 10), II (n = 5), and I (n = 1). The absence of phototype information was also identified in 46% of the collected medical records. As for photoexposure, 22 (34%) had no record of this information, while 43 (66%) had photoexposure. Photoprotection, in turn, was presented in the minority of patients (n = 3) in relation to the majority not photoprotected (n = 25), and this information was not present in 38% (n = 25) of the evaluated medical records. Going to the type of skin cancer, most were diagnosed with BCC (n = 42), followed by Bowen’s Disease (n = 10), SCC (n = 4) and, finally, 8% (n = 4) had other less prevalent alterations. The recurrence of BCC was higher (n = 9) than other types. It is possible to conclude that the general profile with the highest prevalent proportion was of elderly patients, female, phototypes III and IV, without photoprotection, diagnosed with nodular BCC, without recurrence after surgical treatment and lesion removal. However, the scarcity of complete records in the medical records proved to be a limiting factor for measuring potential associations and clarifications.
Avaliação do uso de hidroclorotiazida em pacientes com carcinoma basocelular atendidos em ambulatório de dermatologia
(Centro Universitário do Estado do Pará, 2019-11-20) Rodrigues, Pedro Henrique Pantoja Souza; Franco, Rodrigo Carneiro; Amin, Gabriela Athayde; Carneiro, Francisca Regina Oliveira; http://lattes.cnpq.br/1387234135281918; http://lattes.cnpq.br/8604283847300465; Bittencourt, Maraya de Jesus Semblano; http://lattes.cnpq.br/6566823528602319; Lima, Caren dos Santos; http://lattes.cnpq.br/6225022147519510
Introduction: According to the National Cancer Institute (INCA), nonmelanoma skin cancer represents 30% of all malignant neoplasm in Brazil. These tumors have low lethality but high morbidity, so recognition of risk factors and early diagnosis are determinant for prognosis. Basal cell carcinoma arises from non-keratinized cells from the basal layer of the epidermis and represents 76% of all non-melanoma skin cancer (CPNM). In Brazil, approximately 165,580 new cases of this neoplasm were estimated, with tendency to increase this rate for the next years. It is locally invasive, usually nonagressive and destructive of skin, despite its low metastatic potential, being more common among the elderly, white populations and male. Its main clinical presentation is a papule ou nodule with a pearly aspect, often with typical telangectasy located mainly in the head and neck region. Some studies have related hydrochlorothiazide, one of the main antihypertensive drugs used in Brazil, as a potential risk factor for the development of Basal Cell Carcinoma (CBC). This led the National Health Surveillance Agency (ANVISA) to release a note informing about the increased risk of nonmelanoma skin cancer with the use of the drug and recommending that physicians report this risk to patients, as well to guide patients for regular self-examination of the skin looking for new lesions. Current studies, however, are recent and conflicts about this association. Objective: Evaluate the relationship between hydrochlorothiazide use and the risk of developing basal cell carcinoma. Materials and Methods: A population-based case-control study was conducted, collecting cases (histopathological CBC confirmations) of the Pathology Laboratory of the Dermatology Service of the Center for Medical Specialties of the University Center of Pará (CESUPA). Controls were matched 3:1 by age and sex. Data was obtained from medical record or interview. Analytical statistics were used to evaluate the results of the categorical variables of the sample through the G and Chi-squared tests adherence and independence. Odds Ratio was calculated using Logistic Regression, with a 95% confidence interval. Results: We obtained 36 cases of BCC and 108 controls. The use of hydrochlorothiazide increased the risk of developing basal cell carcinoma (Odds Ratio 2.53 and 95% CI 1.04 - 6.14). There seems to be a cumulative dose relationship, evidenced by Odds ratio 2.80 and 95% CI 1.01 - 7.77 for doses greater than or equal to 27,000mg, corresponding to 3 years or more of use, which is not observed at doses lower than this. Conclusion: The use of hydrochlorothiazide increase the risk of developing basal cell carcinoma.